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                                             洪詩雅    副教授,研究員
所在學院生命科學與技術學院
研究方向巨噬細胞代謝、功能及生物學
聯系方式tsyhorng@@shanghaitech.edu.cn


個人簡介
1995-1999 美國加州大學伯克利, 分子細胞學,學士學位
1999-2003 耶魯大學, 免疫學,博士學位
2003-2007 耶魯大學Ruslan Medzhitov實驗室,博士后研究
2007-2008 哈佛大學醫學院Anjana Rao實驗室百万彩票注册链接,博士后研究
2008-2014 哈佛公衛學院,助理教授
2015-2018 哈佛公衛學院,副教授
2018.10-至今 上??萍即髮W,生命科學與技術學院,副教授,研究員

主要研究內容
巨噬細胞是極具動力性及調節多種生理功能的細胞。本課題組致力于研究巨噬細胞代謝百万彩票注册链接,包括不同代謝途徑與激活巨噬細胞的信號通路之間的相互作用,以及線粒體代謝對染色質的調控作用百万彩票注册链接。課題組的研究目標在闡述細胞代謝調節巨噬細胞功能的主要機理,為多種生理和病理狀態如先天免疫、炎癥等提供前瞻思路及可能的診療手段。

代表性論文

論文

1.  Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. *co-corresponding authors.  Cell. Jul. 10, 2009.
PMID: 19596240

2.  Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer A, and Horng T.  A critical role for calcium mobilization in activation of the NLRP3 inflammasome. PNAS. Jul. 10, 2012.  PMID: 22733741

3.  Byles V*, Covarrubias AJ*, Ben-Sahra I, Lamming D, Sabatini D, Manning B and Horng T.  The TSC-mTOR pathway regulates macrophage polarization. *co-first authorship.  Nature Communications. Nov. 27, 2013. PMID: 24280772

4.  Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM and Horng T.  Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS. Oct. 28, 2014.PMID: 25313054

5.  Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Stapornkul TP, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, and Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. eLIFE. Feb. 19, 2016. PMID: 26894960

·         Commentary by Torres A et al. Immunometabolism: Metabolism fine-tunes macrophage activation. eLIFE. Feb 19, 2016. PMID: 26894957


6.  Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki, Suzuki T, Yamamoto M, Horng T, and Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Science Reports. Aug 18;7(1):8801. PMID: 28821730


7.  Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, and Blander JM. Innate sensing of microbial viability orchestrates stress-mediated autophagy of the endoplasmic reticulum. Cell. Nov 2;171(4):809-823. PMID: 29056340


綜述

1.    Medzhitov R and Horng T*.  Transcriptional control of the inflammatory response. *co-corresponding authors.   Nature Reviews Immunology. Oct. 2009. PMID: 19859064

2.     Horng T and Hotamisligil.  Linking the inflammasome to obesity-related disease.  Nature Medicine. Feb. 2011. PMID: 21297609 

3    Covarrubias A, Byles V, and Horng T.  ROS sets the stage for macrophage differentiation.  Cell Research. Aug. 2013.PMID: 23835480

4.      Kagan JC and Horng T.  NLRP3 inflammasome activation:  CD36 serves double duty.  Nature Immunology. Aug. 2013. PMID: 23867926

5.     Horng, T.  Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.  Trends in Immunology. Jun. 2014. PMID: 24646829 

6.    Covarrubias AJ and Horng T.  IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, Jun. 2014. PMID: 24896536

7.    Horng, T.  mTOR trains heightened macrophage responses. Trends in Immunology. Jan. 2015. PMID: 25488670

9.  Covarrubias AJ, Aksoylar HI and Horng T.  Control of macrophage metabolism and activation by mTOR and Akt signaling.  Seminars in Immunology. Aug. 2015. 
PMID: 26360589

10.  Langston PK, Shibata M and Horng T.  Metabolism supports macrophage activation.  Frontiers in Immunology. Jan. 2017. PMID: 28197151. 


11.  Olivas J and Horng T.  Sugar fuels T cell memory. Nature Cell Biology. Jan. 2018. PMID:29269950.


12.  Jung J, Zeng H, and Horng T. Metabolism as a guiding force for immunity. Nature Cell Biology. In press.


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