|1999 B.S. Kyoto University.|
2004 Ph.D. Kyoto University.
2004-2009 Postdoctoral Fellow Marie Curie Research Institute
2009-2011 JSPS Special Postdoctoral Research Fellow at the University of Cambridge
2011-2018 Group Leader University of Cambridge
2018- Assistant Professor Shanghaitech University
|The cell cycle is one of the most fundamental processes for living organisms and the molecular machinery regulating the cell cycle is evolutionally conserved from yeast to man. My laboratory combines advanced genetic methods and in vivo imaging of the fruit fly Drosophila melanogaster with proteomics and genomics approaches and detailed molecular analysis, in order to uncover universal mechanisms integrating cell division into developmental and homeostatic processes of multicellular organisms (http://www.kimatalab.com/). We have recently discovered that the master cell cycle regulator APC/C ubiquitin ligase couples cell fate determination to the cell cycle by regulating an extracellular signalling pathway and the centrosome (Meghini et al., 2016 Nature Comms; Martins et al., 2017 Dev Cell). We are working with international collaborators: Renata Basto (Institute Curie, France), Andrea Brand (Gurdon Institute, UK), and Marc de la Roche (University of Cambridge, UK), to further explore such coupling mechanisms and to apply the findings in flies into mammalian systems.|
1.Martins T, Meghini F, Florio F, and Kimata Y (Corresponding author) (2017). The APC/C coordinates retinal differentiation with the cell cycle through the Nek2-dependent modulation of Wingless signalling. Developmental Cell, 40(1):67-80
2.Meghini F, Martins T, Tait X, Fujimitsu K, Yamano H, Glover DM, and Kimata Y (Corresponding author) (2016). Targeting of Fzr/CDH1 for timely activation of the APC/C at the centrosome during mitotic exit. Nature Communications, 7: 12607.
3.Haider S, Lipinszki Z, Przewloka MR, Ladak Y, D'Avino PP, Kimata Y, Lio' P, Glover DM (2015). DAPPER: a data-mining resource for protein-protein interactions. BioData Min., 8: 30.
4.Kimata Y, Kitamura K, Fenner N, and Yamano H (2011). Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol. Biol. Cell, 22(9): 1486–94.
5.Kimata Y, Baxter JE, Fry AM, and Yamano H. (2008). A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment. Molecular Cell, 32(4): 576–83.
6.Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, and Yamano H (2008). A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Developmental Cell, 14: 446–454.
7.Hayes MJ*, Kimata Y* (*equal contribution), Wattam SL, Lindon C, Mao G, Yamano H and Fry AM (2006). Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C. Nature Cell Biology, 8: 607–614.