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                                                鮑嵐    特聘教授
所在學院生命科學與技術學院
中科院上海生命科學研究院生物化學與細胞生物學研究所
研究方向神經細胞蛋白質運輸機制與功能(中科院上海生命科學研究院生物化學與細胞生物學研究所研究員)
聯系方式baolan@@sibcb.ac.cn
備注杰青百万彩票注册链接、百人
 
 主要研究內容 
細胞內的蛋白質合成后要被運輸到不同的區域發揮作用百万彩票注册链接,神經元是一種特化的細胞,除了胞體它還具有長的軸突和樹突,因此蛋白質在細胞內的長距離運輸就更為重要。我們實驗室對兩部分的研究內容感興趣,一方面是受體和離子通道運輸的調控機制及在感覺傳遞中的生理病理意義,另一方面是蛋白質運輸的軌道微管翻譯后修飾的調控及對神經元發育和神經系統疾病的影響。
 代表性論文 

1. Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 2794-2807.

2. Bao L*. (2015) Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol. Pain, 11: 61

3. Zhang X, Bao L, Li S. (2015) Opioid receptor trafficking and interaction in nociceptors. Br. J. Pharmacol., 172: 364–374.

4. Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153.

5. Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896.

6. Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling. J. Cell Sci., 126: 542-553.

7. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.

8. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.

9. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.

10. Zhang X and Bao L. (2012) Interaction and regulatory functions of μ- and δ-opioid receptors in nociceptive afferent neurons. Neurosci. Bull., 28: 121-130. (Review)

11. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.

12. Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.

13. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, H?kfelt TGM, Bao L*, and Zhang X*. (2010) Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122.

14. Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.

15. Zhang X*, Bao L* and Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Progress in Neurobiology, 90: 276-283. (Review)

16. Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165–2179.

17. Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J. Cell Sci. 121: 3243-3252.

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