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                                                    劉志杰    正教授
所在學院生命科學與技術學院
iHuman研究所
研究方向結構生物學
聯系方式liuzhj@@shanghaitech.edu.cn
備注百人


個人簡介
1984年獲得天津師范大學物理系學士學位;1994年獲得中國科學院生物物理研究所生物物理學博士學位;1995-1995年在美國匹茲堡大學做博士后;1995-1997年在美國佐治亞大學做博士后;1997-2002年任美國佐治亞大學助理研究員;2002-2006年任美國佐治亞大學副研究員;2006-2013年任中國科學院生物物理研究所 “百人計劃”研究員;2013年5月加入上??萍即髮WiHuman研究所。

主要研究內容
主要從事與人源細胞信號傳導相關蛋白,如G蛋白偶聯受體(GPCR),的結構生物學和基于結構的藥物設計研究。研究工作集中在以下幾個方面: 1、人源細胞信號傳導相關蛋白的結構生物學研究; 2、基于GPCR三維結構的藥物篩選與優化百万彩票注册链接。

代表性論文

1)X. Li, T. Hua, K. Vemuri, S. J. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M. Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos, L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2018) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell, in press. 

2)Y. Peng, J, McCorvy, K, Harps?e, K Lansu, S Yuan, P Popov, L Qu, M Pu, T Che, L Nikolajsen, X Huang, Y Wu, L Shen, W E. Yoshimoto, K Ding, D Wacker, G Han, J Cheng, V Katritch, A A. Jensen, M. Hanson, S Zhao, D E. Gloriam, B L. Roth*, R C. Stevens*, Liu ZJ*, (2018) The Studies of 5-HT2C Receptor Reveal the Structural Basis of GPCR Polypharmacology.Cell, 172(4):719-730. 

3)T. Hua, K. Vemuri, S. Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J.H. Ho, GW. Han, D. Ding, X. Li, H. Liu, S. M. Hanson, S. Zhao*, L. Bohn*, A. Makriyannis*, R Stevens. Liu ZJ* (2017) Crystal Structure of agonist-bound Human Cannabinoid Receptor CB1. Nature, 547 (7664): 468-471 

4)Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu ZJ*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 546(7657):312-315.

5)T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R. Stevens*, Liu ZJ* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.

6)Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6: 7300.

7)J. Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang*, Liu ZJ*, W. Han*, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented EF-Hand-Like Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109.

8)Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu ZJ*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58

9)Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu ZJ*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9.

10)Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu ZJ*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Res, 23(6):855-8. 

11)OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu ZJ*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.

12)Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu ZJ*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover)

13)Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu ZJ*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84.

14)Shaw, N., Cheng, C., and Liu ZJ*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287


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